brief description
The division Molecular Virology has a world-leading position in molecular research on hepatitis viruses (HBV, HDV and HCV) and flaviviruses (e.g. Dengue and Zikavirus). The Molecular Virology is headed by Prof. Bartenschlager and has four research teams (Team Bartenschlager, Lohmann, Ruggieri and Urban) to which more than 50 international members belong. All four project leaders have published in highly renowned journals (Science, Nature, EMBO Journal, Cell Host & Microbes, Nature Medicine etc) with Bartenschlager ~300 papers, h-index 88, Lohmann ~120 papers, h-index 52 , Ruggieri ~30 papers, h-index 15, and Urban ~80 papers, h-index 44.
The Molecular Virology division is located in the Center for Integrative Infectious Disease Research (CIID), a new research building dedicated to infection research, where fully equipped and state-of-the art BSL 1-3 research premises are available. Furthermore access is provided to the Infectious Diseases Imaging Platform (IDIP) that is suitable for image-based read-outs of high-content screens as well as high-end imaging (live, confocal) under biosafety level (BSL) 2 and 3 conditions, the DZIF imaging platforms and the electron microscopy core facility (EMCF) of the cluster of excellence “CellNetworks”.
CIID
Im Neuenheimer Feld 344
1st floor
69120 Heidelberg
President of "Gesellschaft für Virologie (GfV)"
The drug inhibits the entry of Hepatitis D Virus (HDV) and Hepatitis B Virus into liver cells by blocking the viral receptor. Hepcludex has received provisional approval after very favorable data from two phase 2 clinical trials. This approval makes the drug available to patients suffering from chronic hepatitis D.
Jointly with Charles M. Rice and Michael Sofia
Jointly with Charles M. Rice
He will receive the €35,000 prize and a medal at the Dutch Annual Virology Symposium on 5 March 2021.
ZIKAlliance (EU Horizon2020-734548)
ZIKAlliance is a multinational and multi-disciplinary research consortium comprised of 54 partners worldwide. The project will investigate clinical, fundamental, environmental and social aspects of ZIKV infection.
ZIKALLIANCE
Cooperation TRR179-CanHepC
Determinants and dynamics of elimination versus persistence of hepatitis virus infection
Got to TRR179
Clinial trial to assess safety and efficacy of a novel therapy for the treatment of hepatitis D virus infection
Cell Host Microbe. 2020 Dec 9;28(6):853-866.e5. doi: 10.1016/j.chom.2020.11.003. Epub 2020 Nov 17. Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies. Mirko Cortese 1, Ji-Young Lee 2, Berati Cerikan 3, Christopher J Neufeldt 3, Viola M J Oorschot 4, Sebastian Köhrer 5, Julian Hennies 6, Nicole L Schieber 7, Paolo Ronchi 4, Giulia Mizzon 8, Inés Romero-Brey 7, Rachel Santarella-Mellwig 4, Martin Schorb 4, Mandy Boermel 4, Karel Mocaer 7, Marianne S Beckwith 7, Rachel M Templin 7, Viktoriia Gross 7, Constantin Pape 9, Christian Tischer 10, Jamie Frankish 11, Natalie K Horvat 12, Vibor Laketa 13, Megan Stanifer 3, Steeve Boulant 14, Alessia Ruggieri 3, Laurent Chatel-Chaix 15, Yannick Schwab 16, Ralf Bartenschlager 17. Affiliations. PMID: 33245857 PMCID: PMC7670925 DOI: 10.1016/j.chom.2020.11.003
Lohmann V, Körner F, Koch JO, Herian U, Theilmann L, Bartenschlager R. (1999). Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285:110-113. (ct=2170).
Wakita T*, Pietschmann T*, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M, Bartenschlager R* and Liang TJ. (2005). Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Medicine, 11:791-796. * Equal contribution. (ct=2037).
Quinkert D, Bartenschlager R, Lohmann V. (2005). Quantitative analysis of the hepatitis C virus replication complex. J Virol. 79(21):13594-605.(ct=200).
Pietschmann T, Kaul A, Koutsoudakis G, Shavinskaya A, Kallis S, Steinmann E, Abid K, Negro F, Dreux M, Cosset FL, Bartenschlager R. (2006). Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A. 103(19):7408-13. (ct=528).
Schulze A, Gripon P, Urban S. (2007). Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans. Hepatology. 46(6):1759-68. (ct=198).
Petersen J, Dandri M, Mier W, Lütgehetmann M, Volz T, von Weizsäcker F, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S. (2008). Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein. Nat Biotechnol. 26(3):335-41 (ct=247).
Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R. (2009). Composition and three-dimensional architecture of the dengue virus replication and assembly sites. Cell Host Microbe. 5:365-75 (ct=528).
Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R. (2011). Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment. Cell Host Microbe 9(1):32-45. (ct=306).
Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R. (2012). Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe. 12(1):71-85. (ct=88).
Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, Sültmann H, Urban S. (2014). Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology. 146(4):1070-83. (ct=257).
Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S, Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, De Francesco R, Rice CM, Bartenschlager R, Lohmann V. (2016). Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture. Nat Microbiol. 2:16247. (ct=17).
Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A. (2017). Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses. MBio. 8(1). pii: e02150-16 (ct=14).
Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs JAG, Bartenschlager R. (2017). Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses. Cell Host Microbe. 22(3):387-399.
Schult P, Roth H, Adams RL, Mas C, Imbert L, Orlik C, Ruggieri A, Pyle AM, Lohmann V. (2018). microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site. Nat Commun. 9(1):2613.
Neufeldt CJ, Cortese M, Scaturro P, Cerikan B, Wideman JG, Tabata K, Moraes T, Oleksiuk O, Pichlmair A, Bartenschlager R. (2019). ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly. Nat Microbiol. 4(12):2416-2429.
Lempp FA, Schlund F, Rieble L, Nussbaum L, Link C, Zhang Z, Ni Y, Urban S. (2019). Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation. Nat Commun. 10(1):2265.
